In the last few years, the incidence of pulmonary arterial hypertension (PAH) has been increasing in the US, with a prevalence of up to 20% in men and 8% in women (). PAH is a condition that results from an abnormal accumulation of blood in the pulmonary capillaries. The pathophysiology of PAH is largely unknown, and the pathophysiological mechanisms responsible for its development are not well understood. The main pathophysiological mechanisms of PAH are:
Endothelin-1 and vascular endothelial growth factor (VEGF) activation: The vascular endothelium, a complex tissue that carries out essential functions, such as blood vessel formation, proliferation, and repair, has a significant role in the development of PAH. VEGF is a potent stimulator of the growth and proliferation of endothelial cells, exerting its effects through the activation of different receptors that play a central role in vascular remodeling and proliferation. VEGF activates platelets, macrophages, and TNF-α. By blocking its action, VEGF causes the release of nitric oxide (NO), which activates matrix metalloproteinases (MMPs), which can degradation of these proteins. MMP-13, an MMP-8, MMP-1, and MMP-9 enzymes have been shown to be overexpressed in PAH and are involved in the process of degradation of these proteins ().
MMP-9-kinase inhibitors: MMP-9 inhibitors, such as Tadalafil and Cialis, have been found to increase the production of MMP-9 by the endothelial cells of the pulmonary capillary bed. MMP-9 is a pro-MMP-9 protein that is responsible for the degradation of many MMPs. MMP-9-kinase inhibitors, such as Tadalafil and Cialis, are also used to treat PAH. In addition, MMP-9 inhibitors, such as Tadalafil and Cialis, have been found to decrease the levels of MMP-9. Therefore, MMP-9 inhibitors, such as Tadalafil and Cialis, have become a popular treatment for PAH. However, these drugs can only inhibit MMP-9. Therefore, their use in the treatment of PAH is limited.
Tadalafil and Cialis: Tadalafil and Cialis have been proven to reduce MMP-9 production in PAH and can be used as an alternative treatment for PAH in clinical practice. Tadalafil is a phosphodiesterase-5 (PDE-5) inhibitor, which acts by inhibiting PDE-5, an enzyme that is responsible for the degradation of many different MMPs. Cialis, on the other hand, is a PDE-5 inhibitor, which also inhibits PDE-5, an enzyme that is involved in the degradation of MMP-9. Cialis and Tadalafil are used as pulmonary vasodilators. Therefore, both medications can be used to treat PAH in the treatment of PAH.
Cialis: Cialis (tadalafil) is a phosphodiesterase-5 (PDE-5) inhibitor that is used in the treatment of PAH. It has been demonstrated that Cialis can reduce pulmonary vascular resistance and blood pressure in patients with PAH. This reduction in pulmonary vascular resistance is the main mechanism of the increased pulmonary arterial pressure. Therefore, Cialis may be a useful treatment for PAH in the treatment of PAH.
Tadalafil: Tadalafil is a phosphodiesterase-5 (PDE-5) inhibitor that can cause a reduction in the levels of PDE-5, which is responsible for the degradation of many MMPs. Tadalafil is a PDE-5 inhibitor that is used in the treatment of PAH.
: Cialis, a PDE-5 inhibitor, is used to treat PAH. It can reduce the levels of PDE-5, which is responsible for the degradation of many MMPs. Cialis may also be used to treat PAH.
: Tadalafil is a PDE-5 inhibitor that is used in the treatment of PAH.
As with any drug product, there may be side effects. Generally, patients who experience side effects usually get them within 12 to 24 hours after taking Tadalafil. Side effects usually resolve on their own within 48 hours. Daily Tadalafil use is usually associated with lower incidents and severity of side effects compared to as-needed Tadalafil dosing.
Most common Tadalafil side effects
Some more serious side effects have been reported. While rare, it is important to stop taking Tadalafil and contact a doctor right away if any of the following occur:
For a complete list of possible side effects,.
Possible drug interactions
Some drugs/medications may interact with Tadalafil. You should not take Tadalafil if you are taking nitrates (such as nitroglycerin tablets or patches) because the combination of these with Tadalafil could significantly lower blood pressure and lead to fainting or even death. Additionally, do not take Tadalafil if you are taking Cisapride, other ED medications (e.g. Viagra), Adcirca, or Riociguat.
On your intake form, please be sure to provide AgelessRx with all medications, herbs, non-prescription drugs, or dietary supplements you use. Also be sure to report if you smoke, drink alcohol, or use illegal drugs, as some may interact with your medication.
For a complete list of possible drug interactions,.
Other important safety information
Patients who have a condition called “left ventricular outlet obstruction” from valvular problems or heart muscle enlargement may get side effects such as fainting or light-headedness. Because patients with recent heart attacks or stroke, heart pains (angina), heart failure, uncontrolled blood pressure or uncontrolled irregular heart beats, severe liver disease, and retinal eye problems have not been studied, Tadalafil (Cialis) is not recommended for these patients. There may be rare occurrences of priapism or painful, prolonged erections. This is a serious condition that requires immediate medical attention. Patients should seek prompt medical attention if their erection lasts longer than four hours.
After taking a single tablet, Tadalafil can remain in the body for up to two days. It can remain longer if patients have problems with their kidneys or liver, or they are taking certain other medications.
Note:All information included on this page is a summary. It may not cover all possible information. If you have questions about this medication, talk to a doctor, pharmacist, or healthcare provider.
Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Erectile dysfunction has been reported in association with Tadalafil. Some have suggested that this drug may prevent the ability of patients to get an erection.
Many medicines can cause side effects, and a few may be safe or have drug interactions. The time of the most common side effects reported were headache (30.2%), indigestion (22.6%), nasal congestion (15.1%), and skin rash (11.9%). More serious side effects have been reported with Tadalafil than with other branded medications ( headache (30.2% of those reported), indigestion (14.8%), and back pain (9.1%).
1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).
2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.
3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.
Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:
Combining Cialis with nitrates can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or stroke, a condition known as nitrates. This can lead to symptoms like dizziness, fainting, or even heart attack or blood clotting disorder, such as a heart attack or stroke.
Whether you can take Tadalafil at the same time as your other medications will depend on which medications you are taking.
You are required to complete a short medical consultation questionnaire that asks for any medications that you are prescribed from your GP and will indicate the medications that can’t be taken alongside Tadalafil.
There are several medicines which should not be taken concurrently with Tadalafil. Medicines which can have potentially serious interactions with Tadalafil include :-
• Any alpha-blocker medicines e.g. doxazosin (Cardura), alfuzosin (Xatral), tamsulosin, terazosin, or Flomax, that you can buy in the pharmacy. (These medicines may be used to treat prostate problems or high blood pressure).
• Isosorbide mononitrate, isosorbide dinitrate, or use a GTN spray or tablets
for chest pain or use Rectogesic ointment?
• Nicorandil (Ikorel), used to treat angina
• Cimetidine, used to treat stomach or duodenal (peptic) ulcers
• Theophylline, used to treat asthma
• Antibiotics:- Clarithromycin, Erythromycin and Telithromycin
• Anti-fungals such as itraconazole and ketoconazole
• Seizure medication:- carbamazepine, oxcarbazepine, phenobarbital, phenytoin and primidone
• Heart or blood pressure medication:- disopyramide, amiodarone, quinidine and procainamide
• Anti-viral medication:- telaprevir, atazanavir, retonavir, indinavir, saquinavir and cobicistat
• Recreational drugs:- amyl nitrate (poppers)
If you are taking any prescribed medication from your GP then you can simply write those in the “Is there any other medical information that you think our doctor should know?” section on the medical questionnaire. Then, our doctor will know whether the Tadalafil is safe for you to take.
Read available consultation questionnaire information online for<
Read available consultation questionnaire information for>
Tadalafil can’t be takenThe main difference is in the amount of time Tadalafil will be taken before your next sexual activity, called a sexual activity. Tadalafil is taken about once per day and the effects can last up to about four hours after you’re completely bound to your sexual activity.
When you have a sexual activity, you take Tadalafil once a day. It’s taken for up to four hours for your condition to be well. You have to start your sexual activity again after you’re completely bound to your sexual activity, and that’s usually how long you’ll have sex.
We’re careful not to mention that you’ll only have sex when you need it most, about 4 hours after you’re completely bound to your sexual activity.
Tadalafil can be taken with or without food. It’s important to do your medicine on a time-to-dos days (or earlier) rather than a time-daily time cut-off.
There are also some differences in the packaging, dosage and other important details that can affect the dosage of Tadalafil and your potential risks.
You should also be careful not to share your complete medical history with anyone, even if it be a doctor or a union between you.
You should self-medication.
Stade de France Pharmacy